Regulation of rDNA transcription in response to growth factors, nutrients and energy

EP Kusnadi; KM Hannan; RJ Hicks; RD Hannan; RB Pearson; J Kang

Journal article

Regulation of rDNA transcription in response to growth factors, nutrients and energy

EP Kusnadi, KM Hannan, RJ Hicks, RD Hannan, RB Pearson, J Kang

Gene | Published : 2015

DOI: 10.1016/j.gene.2014.11.010

Abstract

Exquisite control of ribosome biogenesis is fundamental for the maintenance of cellular growth and proliferation. Importantly, synthesis of ribosomal RNA by RNA polymerase I is a key regulatory step in ribosome biogenesis and a major biosynthetic and energy consuming process. Consequently, ribosomal RNA gene transcription is tightly coupled to the availability of growth factors, nutrients and energy. Thus cells have developed an intricate sensing network to monitor the cellular environment and modulate ribosomal DNA transcription accordingly. Critical controllers in these sensing networks, which mediate growth factor activation of ribosomal DNA transcription, include the PI3K/AKT/mTORC1, RAS..

View full abstract

University of Melbourne Researchers

Richard Pearson Author

Jian Kang Author

Eric Kusnadi Author

Related Projects (6)

AKT regulation of growth and proliferation

Ribosome synthesis and function is critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely,..

New therapies for MYC-associated cancers

This proposal will evaluate a new strategy for treating cancers associated with the cancer causing gene MYC. Globally there are more than 1 ..

ONCOGENIC SIGNALING AND CANCER THERAPY

Central to improving the management of patients with cancer is an understanding of the molecular drivers of cancer. Based on our fundamental..

A NEW APPROACH TO TARGETING CELL GROWTH FOR THE TREATMENT OF CANCER

We have made the fundamental discovery that ribosomal gene transcription is not simply a 'house keeping' process in cancer cells but is requ..

Pol I and Myc driven malignacy

Synthesis of ribosomes, the cellular protein synthetic machinery, is dysregulated during cancer leading to the hypothesis that it may be cau..

UTILISING PI3K/AKT-DEPENDENT SENESCENCE TO TREAT CANCER

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) (509087; 566876; 1044881; 1042890; 1053792:566771; 1003270; 1038852) of Australia project and program grants, the Cancer Council Victoria (1065118), Prostate Cancer Foundation of Australia (CG1511); the Leukaemia Foundation, and the Captain Courageous Foundation (ADBA #1). Researchers were funded by NHMRC Fellowships (R.D.H. and R.B.P.) and a Melbourne International Research Scholarship (E.P.K.). We apologize to the authors of many primary research papers that were not cited here due to space constraints but whose work influenced our understanding substantively.